GM-CSF action in the CNS decreases food intake and body weight.

  title={GM-CSF action in the CNS decreases food intake and body weight.},
  author={Jacquelyn A Huffman Reed and Deborah J. Clegg and Kathleen A Blake Smith and Emeline G Tolod-Richer and Emily K. Matter and Lara S Picard and Randy J Seeley},
  journal={The Journal of clinical investigation},
  volume={115 11},
Many proinflammatory cytokines, such as leptin, play key roles in dynamic regulation of energy expenditure and food intake. The present work tested a role for the proinflammatory cytokine GM-CSF. Central but not peripheral administration of GM-CSF to adult rats significantly decreased food intake and body weight for at least 48 hours. Similar results were observed following central administration of GM-CSF in mice. GM-CSF receptor immunoreactivity was found on neurons within the paraventricular… CONTINUE READING

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