GLYX-13: A monoclonal antibody-derived peptide that acts as an N-methyl-d-aspartate receptor modulator

@article{Moskal2005GLYX13AM,
  title={GLYX-13: A monoclonal antibody-derived peptide that acts as an N-methyl-d-aspartate receptor modulator},
  author={Joseph r. Moskal and Amy G. Kuo and Craig Weiss and Paul L Wood and Amy O'Connor Hanson and Stephen R. Kelso and Robert B. Harris and John F. Disterhoft},
  journal={Neuropharmacology},
  year={2005},
  volume={49},
  pages={1077-1087}
}
We previously created a monoclonal antibody (MAb), B6B21, that acts as a partial agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor [Moskal, J.R., Schaffner, A.E., 1986. Monoclonal antibodies to the dentate gyrus: immunocytochemical characterization and flow cytometric analysis of hippocampal neurons bearing a unique cell-surface antigen. J. Neurosci. 6, 2045-2053.]. The hypervariable region of the light chain of B6B21 was cloned and sequenced. Peptides were then… 
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Several targets to “correct” or “reset” the NMDARMN in these CNS disorders have been identified and confirmed, including the glycine/ d -serine co-agonist site, channel ionophore, glycine transporter-1, and d -amino acid oxidase.
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