GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

  title={GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes},
  author={A. Stenbit and Tsu-Shuen Tsao and J. Li and R. Burcelin and D. Geenen and S. Factor and K. Houseknecht and E. B. Katz and M. Charron},
  journal={Nature Medicine},
  • A. Stenbit, Tsu-Shuen Tsao, +6 authors M. Charron
  • Published 1997
  • Medicine
  • Nature Medicine
  • GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 expression on whole-body glucose homeostasis, we disrupted the murine GLUT4 gene by homologous recombination. Male mice heterozygous for the mutation (GLUT+/−) exhibited a decrease in GLUT4 expression in… CONTINUE READING
    337 Citations
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