GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes

@inproceedings{Koumanov2012GLUT4TT,
  title={GLUT4 Traffic through an ESCRT-III-Dependent Sorting Compartment in Adipocytes},
  author={Francoise Koumanov and Vinit J. Pereira and Paul Whitley and Geoffrey David Holman},
  booktitle={PloS one},
  year={2012}
}
In insulin target tissues, GLUT4 is known to traffic through multiple compartments that may involve ubiquitin- and/or SUMO-dependent targeting. During these trafficking steps, GLUT4 is sorted into a storage reservoir compartment that is acutely released by insulin signalling processes that are downstream of PI 3-kinase associated changes in inositol phospholipids. As ESCRT components have recently been found to influence cellular sorting processes that are related to changes in both… CONTINUE READING

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