GLUT2 is a high affinity glucosamine transporter.

  title={GLUT2 is a high affinity glucosamine transporter.},
  author={Marc Uldry and Mark Ibberson and Masaya Hosokawa and Bernard Thorens},
  journal={FEBS letters},
  volume={524 1-3},
When expressed in Xenopus oocytes, GLUT1, 2 and 4 transport glucosamine with V(max) values that are three- to four-fold lower than for glucose. The K(m)s for glucosamine and glucose of GLUT1 and GLUT4 were similar. In contrast, GLUT2 had a much higher apparent affinity for glucosamine than for glucose (K(m)=0.8+/-0.1 mM vs. approximately 17-20 mM). Glucosamine transport by GLUT2 was confirmed in mammalian cells and, using hepatocytes from control or GLUT2-null mice, HgCl(2)-inhibitable… CONTINUE READING