GLUT2 is a high affinity glucosamine transporter

@article{Uldry2002GLUT2IA,
  title={GLUT2 is a high affinity glucosamine transporter},
  author={M. Uldry and M. Ibberson and Masaya Hosokawa and B. Thorens},
  journal={FEBS Letters},
  year={2002},
  volume={524}
}
  • M. Uldry, M. Ibberson, +1 author B. Thorens
  • Published 2002
  • Medicine, Biology
  • FEBS Letters
  • When expressed in Xenopus oocytes, GLUT1, 2 and 4 transport glucosamine with V max values that are three‐ to four‐fold lower than for glucose. The K ms for glucosamine and glucose of GLUT1 and GLUT4 were similar. In contrast, GLUT2 had a much higher apparent affinity for glucosamine than for glucose (K m=0.8±0.1 mM vs. ∼17–20 mM). Glucosamine transport by GLUT2 was confirmed in mammalian cells and, using hepatocytes from control or GLUT2‐null mice, HgCl2‐inhibitable glucosamine uptake by liver… CONTINUE READING
    255 Citations

    Topics from this paper.

    Mouse GLUT9: evidences for a urate uniporter.
    • 86
    • PDF
    Small Molecule Modulation of GLUT1-Mediated Glucose Transport
    Cloning and Distribution of Facilitative Glucose Transporter 2 (SLC2A2) in Pigs
    • 8
    • PDF
    Facilitative glucose transporter and its regulation by insulin/IGF-like signaling in Caenorhabditis elegans
    • 1
    • Highly Influenced
    The SLC2 (GLUT) family of membrane transporters.
    • 584
    • PDF
    Tracking GLUT2 Translocation by Live-Cell Imaging.
    • 3
    Title : The SLC 2 ( GLUT ) family of membrane transporters
    • 11

    References

    SHOWING 1-10 OF 33 REFERENCES
    Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.
    • 311
    • PDF
    Role of the glucosamine pathway in fat-induced insulin resistance.
    • 296
    • PDF