GLUT2 is a high affinity glucosamine transporter

  title={GLUT2 is a high affinity glucosamine transporter},
  author={M. Uldry and M. Ibberson and Masaya Hosokawa and B. Thorens},
  journal={FEBS Letters},
  • M. Uldry, M. Ibberson, +1 author B. Thorens
  • Published 2002
  • Medicine, Biology
  • FEBS Letters
  • When expressed in Xenopus oocytes, GLUT1, 2 and 4 transport glucosamine with V max values that are three‐ to four‐fold lower than for glucose. The K ms for glucosamine and glucose of GLUT1 and GLUT4 were similar. In contrast, GLUT2 had a much higher apparent affinity for glucosamine than for glucose (K m=0.8±0.1 mM vs. ∼17–20 mM). Glucosamine transport by GLUT2 was confirmed in mammalian cells and, using hepatocytes from control or GLUT2‐null mice, HgCl2‐inhibitable glucosamine uptake by liver… CONTINUE READING
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