GLUT-1 expression in the cerebra of patients with Alzheimer's disease.

@article{Mooradian1997GLUT1EI,
  title={GLUT-1 expression in the cerebra of patients with Alzheimer's disease.},
  author={Arshag D Mooradian and Hyun Chul Chung and Gul N. Shah},
  journal={Neurobiology of aging},
  year={1997},
  volume={18 5},
  pages={469-74}
}
To investigate the molecular basis of reduced GLUT-1 concentration of the blood-brain barrier in patients with Alzheimer's disease (AD), the GLUT-1 mass, mRNA content, and structure were studied in eight patients with AD and seven age-matched controls. The results indicate that the 55-kDa GLUT-1 is significantly reduced in AD without a significant change in GLUT-1 mRNA concentrations. Because in some animal models changes in GLUT-1 expression is associated with changes in GLUT-1 mRNA structure… CONTINUE READING