GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier

  title={GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier},
  author={G. Seidner and M. G. Alvarez and Jih-I Yeh and K. R. O'Driscoll and J. Klepper and T. Stump and D. Wang and N. Spinner and M. Birnbaum and D. C. D. Vivo},
  journal={Nature Genetics},
  • G. Seidner, M. G. Alvarez, +7 authors D. C. D. Vivo
  • Published 1998
  • Medicine, Biology
  • Nature Genetics
  • The high metabolic requirements of the mammalian central nervous system require specialized structures for the facilitated transport of nutrients across the blood-brain barrier. Stereo-specific high-capacity carriers, including those that recognize glucose, are key components of this barrier, which also protects the brain against noxious substances. Facilitated glucose transport in vertebrates is catalyzed by a family of carriers consisting of at least five functional isoforms with distinct… CONTINUE READING
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