GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

  title={GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder},
  author={Jake Andrew Deckert and Heike Weber and Carmen Villmann and Tina B. Lonsdorf and Jan Richter and Marta Andreatta and Alejandro Arias-Vasquez and Leif G. Hommers and Lindsey Kent and Christoph Schartner and Sven Cichon and Christiane Wolf and Nancy Schaefer and Cora R. von Collenberg and Britta Wachter and R. Doutor Heitor Blum and Dirk Sch{\"u}mann and Robert Scharfenort and Johannes Schumacher and A J Forstner and Christian Baumann and Miriam A. Schiele and Swantje Notzon and Peter Zwanzger and Joost G. E. Janzing and Tessel E. Galesloot and Lambertus A.L.M. Kiemeney and Agnieszka Gajewska and Evelyn Glotzbach-Schoon and Andreas M{\"u}hlberger and Georg W. Alpers and Thomas Fydrich and Lydia Fehm and Alexander L. Gerlach and Tilo T. J. Kircher and Thomas Lang and Andreas Str{\"o}hle and Volker Arolt and Hans-Ulrich Wittchen and Raffael Kalisch and Christian B{\"u}chel and Alfons O. Hamm and Markus M. N{\"o}then and Marcel Romanos and Katharina Domschke and Paul Pauli and Andreas Reif},
  journal={Molecular Psychiatry},
The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave 1. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants… 

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