GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.

@article{Koehler2015GLP1RAP,
  title={GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.},
  author={Jacqueline A. Koehler and Laurie L. Baggio and Bernardo Yusta and Christine Longuet and Katherine J. Rowland and Xiemin Cao and Dianne P Holland and Patricia L Brubaker and Daniel J Drucker},
  journal={Cell metabolism},
  year={2015},
  volume={21 3},
  pages={379-91}
}
Glucagon-like peptide-1 (GLP-1) secreted from enteroendocrine L cells promotes nutrient disposal via the incretin effect. However, the majority of L cells are localized to the distal gut, suggesting additional biological roles for GLP-1. Here, we demonstrate that GLP-1 receptor (GLP-1R) signaling controls mucosal expansion of the small bowel (SB) and colon. These actions did not require the epidermal growth factor (EGF) or intestinal epithelial insulin-like growth factor (IGF1) receptors but… CONTINUE READING

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These actions did not require the epidermal growth factor ( EGF ) or intestinal epithelial insulin - like growth factor ( IGF1 ) receptors but were absent in Glp1r(-/- ) mice .
These actions did not require the epidermal growth factor ( EGF ) or intestinal epithelial insulin - like growth factor ( IGF1 ) receptors but were absent in Glp1r(-/- ) mice .
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