GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

@inproceedings{Iwasaki2017GLP1RA,
  title={GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose},
  author={Yusaku Iwasaki and Mio Sendo and Katsuya Dezaki and Tohru Hira and Takehiro Sato and Masanori Nakata and Chayon Goswami and Ryohei Aoki and Takeshi Arai and Parmila Kumari and Masaki Hayakawa and Chiaki Masuda and Takashi Okada and Hiroshi Hara and Daniel J Drucker and Yuichiro Yamada and Masaaki Tokuda and Toshihiko Yada},
  booktitle={Nature Communications},
  year={2017}
}
Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar d-allulose (d-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces… CONTINUE READING