GLP-1 receptor agonist increases the expression of CTRP3, a novel adipokine, in 3T3-L1 adipocytes through PKA signal pathway.

@article{Li2015GLP1RA,
  title={GLP-1 receptor agonist increases the expression of CTRP3, a novel adipokine, in 3T3-L1 adipocytes through PKA signal pathway.},
  author={Xin Li and Liu Jiang and Miao Yang and Yu-Wen Wu and Su-xin Sun and Jia-Zhong Sun},
  journal={Journal of endocrinological investigation},
  year={2015},
  volume={38 1},
  pages={73-9}
}
OBJECTIVE To investigate the effects of Exendin-4 (Ex-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, on the expression of C1q/TNF-related protein-3 (CTRP3), a novel adipokine, in 3T3-L1 adipocytes. The role of protein kinase A (PKA) signal pathway in the effects was also investigated. METHODS The mRNA and protein expressions of CTRP3 in 3T3-L1 adiocytes were detected by real-time polymerase chain reaction and western blot, respectively. Exendin-fragment 9-39 (Ex-9), a specific GLP-1… CONTINUE READING

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