GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve.

@article{Brandt2001GLP1inducedAI,
  title={GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve.},
  author={A. Brandt and M. Katschinski and R. Arnold and K. Polonsky and B. G{\"o}ke and M. Byrne},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 2},
  pages={
          E242-7
        }
}
The present study was undertaken to establish in normal volunteers the alterations in beta-cell responsiveness to glucose associated with a constant infusion of glucagon-like peptide-1 (GLP-1) or a pretreatment infusion for 60 min. A high-dose graded glucose infusion protocol was used to explore the dose-response relationship between glucose and insulin secretion. Studies were performed in 10 normal volunteers, and insulin secretion rates (ISR) were calculated by deconvolution of peripheral C… Expand
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References

SHOWING 1-10 OF 37 REFERENCES
Insulin secretion and clearance during low-dose graded glucose infusion.
  • 96
Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice.
  • B. Ahrén, G. Pacini
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
  • 1999
  • 58
  • PDF
Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans.
  • 95
Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.
  • 183
  • PDF
Constitution of a biphasic insulin response to glucose in human fetal pancreatic beta-cells with glucagon-like peptide 1.
  • 41
...
1
2
3
4
...