GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid.

@article{Gault2008GLP1AF,
  title={GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid.},
  author={Victor A Gault and Christian H{\"o}lscher},
  journal={European journal of pharmacology},
  year={2008},
  volume={587 1-3},
  pages={112-7}
}
Type 2 diabetes mellitus has been identified as a risk factor for Alzheimer's disease, and insulin signalling is often impaired in Alzheimer's disease, contributing to the neurodegenerative process. One potential strategy to help prevent this is the normalisation of insulin signalling in the brain. Therefore, the present study was designed to test the effects of the insulin-releasing gut hormone, glucagon-like peptide 1 (GLP-1). A protease-resistant form of GLP-1, (Val8)GLP-1, was also tested… CONTINUE READING

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