GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs.

  title={GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs.},
  author={Dariush H Elahi and Franca S Angeli and Amin Vakilipour and Olga D Carlson and E Deloya Tomas and Josephine M. Egan and Joel Francis Habener and Richard P. Shannon},
We have previously demonstrated in human subjects who under euglycemic clamp conditions GLP-1(9-36)amide infusions inhibit endogenous glucose production without substantial insulinotropic effects. An earlier report indicates that GLP-1(9-36)amide is cleaved to a nonapeptide, GLP-1(28-36)amide and a pentapeptide GLP-1(32-36)amide (LVKGR amide). Here we study the effects of the pentapeptide on whole body glucose disposal during hyperglycemic clamp studies. Five dogs underwent indwelling… CONTINUE READING

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GLP - 1derived pentapeptide GLP - 1 ( 32 – 36 ) amide attenuates the development of obesity , diabetes , hepatic steatosis , and increases energy expenditure in dietinduced obese mice [ abstract ]

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