GLO1 overexpression in human malignant melanoma.


Glyoxalase I [lactoylglutathione lyase (EC encoded by GLO1] is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis. Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellular damage associated… (More)
DOI: 10.1097/CMR.0b013e3283364903