GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

@inproceedings{Srivastava2014GLIIG,
  title={GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis},
  author={Ritesh Kumar Srivastava and Samer Zaid Kaylani and Nayf Edrees and Changzhao Li and Sarang S. Talwelkar and Jian-min Xu and Komaraiah Palle and Joseph G Pressey and Mohammad Athar},
  booktitle={Oncotarget},
  year={2014}
}
Rhabdomyosarcoma (RMS) typically arises from skeletal muscle. Currently, RMS in patients with recurrent and metastatic disease have no successful treatment. The molecular pathogenesis of RMS varies based on cancer sub-types. Some embryonal RMS but not other sub-types are driven by sonic hedgehog (Shh) signaling pathway. However, Shh pathway inhibitors… CONTINUE READING