GITR Intrinsically Sustains Early Type 1 and Late Follicular Helper CD4 T Cell Accumulation to Control a Chronic Viral Infection

@inproceedings{Clouthier2015GITRIS,
  title={GITR Intrinsically Sustains Early Type 1 and Late Follicular Helper CD4 T Cell Accumulation to Control a Chronic Viral Infection},
  author={Derek Leonard Clouthier and Angela C. Zhou and Michael E. Wortzman and Olga Luft and Gary A. Levy and Tania H Watts},
  booktitle={PLoS pathogens},
  year={2015}
}
CD4 T cells are critical for control of persistent infections; however, the key signals that regulate CD4 T help during chronic infection remain incompletely defined. While several studies have addressed the role of inhibitory receptors and soluble factors such as PD-1 and IL-10, significantly less work has addressed the role of T cell co-stimulatory molecules during chronic viral infection. Here we show that during a persistent infection with lymphocytic choriomeningitis virus (LCMV) clone 13… CONTINUE READING
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