GIT1 paxillin-binding domain is a four-helix bundle, and it binds to both paxillin LD2 and LD4 motifs.

@article{Zhang2008GIT1PD,
  title={GIT1 paxillin-binding domain is a four-helix bundle, and it binds to both paxillin LD2 and LD4 motifs.},
  author={Ziwei M. Zhang and Joseph A Simmerman and Cristina D. Guibao and Jie J. Zheng},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 27},
  pages={18685-93}
}
The G protein-coupled receptor kinase-interacting protein 1 (GIT1) is a multidomain protein that plays an important role in cell adhesion, motility, cytoskeletal remodeling, and membrane trafficking. GIT1 mediates the localization of the p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions, and its activation is regulated by the interaction between its C-terminal paxillin-binding domain (PBD) and the LD motifs of paxillin. In this study, we determined the solution… CONTINUE READING