GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice

  title={GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice},
  author={Hyejung Won and Won Mah and EunJin Kim and Jae-Won Kim and Eun-Kyoung Hahm and Myoung-Hwan Kim and Sukhee Cho and Jeong Jin Kim and Hyeran Jang and Soo-Churl Cho and Bung Nyun Kim and Min-Sup Shin and Jinsoo Seo and Jaeseung Jeong and Se-Young Choi and Daesoo Kim and Changwon Kang and Eunjoon Kim},
  journal={Nature Medicine},
Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder that affects ∼5% of school-aged children; however, the mechanisms underlying ADHD remain largely unclear. Here we report a previously unidentified association between G protein–coupled receptor kinase–interacting protein-1 (GIT1) and ADHD in humans. An intronic single-nucleotide polymorphism in GIT1, the minor allele of which causes reduced GIT1 expression, shows a strong association with ADHD susceptibility in humans… CONTINUE READING
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Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder

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