GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.

@article{Giovannone2009GIGYF2GD,
  title={GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.},
  author={Barbara Giovannone and William G. Tsiaras and Suzanne de la Monte and Jan Klysik and Corinne Lautier and Galina Karashchuk and Stefano Goldwurm and Robert J. Smith},
  journal={Human molecular genetics},
  year={2009},
  volume={18 23},
  pages={4629-39}
}
Grb10-Interacting GYF Protein 2 (GIGYF2) was initially identified through its interaction with Grb10, an adapter protein that binds activated IGF-I and insulin receptors. The GIGYF2 gene maps to human chromosome 2q37 within a region linked to familial Parkinson's disease (PARK11 locus), and association of GIGYF2 mutations with Parkinson's disease has been described in some but not other recent publications. This study investigated the consequences of Gigyf2 gene disruption in mice. Gigyf2 null… CONTINUE READING