GHKL, an emergent ATPase/kinase superfamily.

@article{Dutta2000GHKLAE,
  title={GHKL, an emergent ATPase/kinase superfamily.},
  author={Rinku Dutta and M. Inouye},
  journal={Trends in biochemical sciences},
  year={2000},
  volume={25 1},
  pages={24-8}
}
An interesting recent development is the recognition of a novel ATP-binding superfamily that includes diverse protein families such as DNA topoisomerase II, molecular chaperones Hsp90, DNA-mismatch-repair enzymes MutL and histidine kinases. The most singular unifying feature of this superfamily is the unconventional Bergerat ATP-binding fold. The far-reaching significance of this commonality is still in the process of being explored. 
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