• Corpus ID: 53060119

GHK – Copper Peptide in Skin Remodeling and Anti-Aging ! GHK-Cu in Skin Remodeling

  title={GHK – Copper Peptide in Skin Remodeling and Anti-Aging ! GHK-Cu in Skin Remodeling},
  author={A. Margolina L. Pickart},
Although copper-binding tri-peptide glycyl-L-histidyl-L-lysine (GHK-Cu) was first discovered as an activity that makes old liver cells behave like young cells, the following studies soon began to focus on its wound healing and skin remodeling activity. These studies provided valuable insight into GHK-Cu’s molecular actions and revealed many mechanisms by which GHK-Cu exhibits anti-aging and tissue renewing properties. In particular it has been established that GHK-Cu can increase production of… 

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The human tri-peptide GHK and tissue remodeling

  • L. Pickart
  • Biology, Medicine
    Journal of biomaterials science. Polymer edition
  • 2008
GHK-Cu stimulates wound healing in numerous models and in humans, and improves hair transplant success, protects hepatic tissue from tetrachloromethane poisoning, blocks stomach ulcer development, and heals intestinal ulcers and bone tissue.

Copper–GHK increases integrin expression and p63 positivity by keratinocytes

Treatment with copper–GHK may increase the proliferative potential of basal keratinocytes by modulating the expression of integrins, p63 and PCNA, and increased levels of p63, a putative stem cell marker of the skin, suggests that copper– GHK promotes the survival of basal stem cells in the skin.

Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation.

It is proposed that GHK:Cu(II) binds to the channels of ferritin involved in iron release and physically prevents the release of Fe(II), and may be the inhibition offerritin iron release in damaged tissues, preventing inflammation and microbial infections.

SPARC is a source of copper-binding peptides that stimulate angiogenesis

Specific degradation of SPARC, a matrix-associated protein expressed by endothelial cells during vascular remodeling, releases a bioactive peptide or peptides, containing the sequence (K)GHK, that could regulate angiogenesis in vivo.

The effect of tripeptide-copper complex on human hair growth in vitro

It is proposed that AHK-Cu promotes the growth of human hair follicles, and this stimulatory effect may occur due to stimulation of the proliferation and the preclusion of the apoptosis of DPCs.

Biological activities of selected peptides: skin penetration ability of copper complexes with peptides.

It is demonstrated that copper complexes permeate through the membranes modeling the horny lipid layer and showed the influence of peptides on the dynamics of copper ion diffusion.

In vitro observations on the influence of copper peptide aids for the LED photoirradiation of fibroblast collagen synthesis.

LED-PI maintained human fibroblast viability and increased collagen synthesis when applied by itself and led to an increase not only in bFGF secretion but also in P1CP production and COL1 mRNA expression compared with LED-PI alone.

Effect of tripeptide-copper complexes on the process of skin wound healing and on cultured fibroblasts.

A slower reorganization of the skin and a delayed activation of fibroblasts are the main effects observed with these peptides-Cu complexes.