GH enhances proliferation of human hepatocytes grafted into immunodeficient mice with damaged liver.

@article{Masumoto2007GHEP,
  title={GH enhances proliferation of human hepatocytes grafted into immunodeficient mice with damaged liver.},
  author={Norio Masumoto and Chise Tateno and Asato Tachibana and Rie Utoh and Yoshio Morikawa and Takashi L Shimada and Hiroyuki Momisako and Toshiyuki Itamoto and Toshimasa Asahara and Katsutoshi Yoshizato},
  journal={The Journal of endocrinology},
  year={2007},
  volume={194 3},
  pages={529-37}
}
We investigated effects of human (h) GH on the proliferation of h-hepatocytes that had been engrafted in the liver of albumin enhancer/promoter driven-urokinase plasminogen activator transgenic/severe combined immunodeficiency disease (uPA/SCID) mice (chimeric mice). The h-hepatocytes therein were considered to be deficient in GH, because hGH receptor (hGHR) is unresponsive to mouse GH. Actually, hIGF-1 was undetectable in chimeric mouse sera. The uPA/SCID mice were transplanted with h… CONTINUE READING