GGDEF domain is homologous to adenylyl cyclase.

  title={GGDEF domain is homologous to adenylyl cyclase.},
  author={Jimin Pei and Nick V. Grishin},
  volume={42 2},
The GGDEF domain is detected in many prokaryotic proteins, most of which are of unknown function. Several bacteria carry 12-22 different GGDEF homologues in their genomes. Conducting extensive profile-based searches, we detect statistically supported sequence similarity between GGDEF domain and adenylyl cyclase catalytic domain. From this homology, we deduce that the prokaryotic GGDEF domain is a regulatory enzyme involved in nucleotide cyclization, with the fold similar to that of the… CONTINUE READING

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