GFRalpha3 is expressed predominantly in nociceptive sensory neurons.

@article{Orozco2001GFRalpha3IE,
  title={GFRalpha3 is expressed predominantly in nociceptive sensory neurons.},
  author={Olivia E. Orozco and Lee Walus and Dinah W. Y. Sah and Robert Blake Pepinsky and Michele Sanicola},
  journal={The European journal of neuroscience},
  year={2001},
  volume={13 11},
  pages={2177-82}
}
Activation of the RET receptor tyrosine kinase by glial-derived neurotrophic factor family members is dependent on a family of coreceptors, GFRalpha1-4. GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family of ligands, artemin. The major site of GFRalpha3 expression is in the dorsal root ganglion; however, the class of sensory neurons that expresses GFRalpha3 has not been reported previously. Using immunohistochemical methods, we show that the majority… CONTINUE READING
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