GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

  title={GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney},
  author={Grace Cacalano and Isabel Fari{\~n}as and Li-chong Wang and Kelly Hagler and Alison Forgie and Mark W. Moore and Mark P. Armanini and Heidi Phillips and Anne M. Ryan and Louis French Reichardt and Mary Hynes and Alun C. Davies and Arnon Rosenthal},
Glial cell line-derived neurotrophic factor (GDNF) is a distant member of the TGFbeta protein family that is essential for neuronal survival and renal morphogenesis. We show that mice who are deficient in the glycosyl-phosphatidyl inositol (GPI) -linked protein GFRalpha1 (GDNFRalpha) display deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons that are strikingly similar to those of the GDNF- and Ret-deficient mice. GFRalpha1-deficient dopaminergic and… CONTINUE READING
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