GFP expression in muscle cells impairs actin-myosin interactions: implications for cell therapy

@article{Agbulut2006GFPEI,
  title={GFP expression in muscle cells impairs actin-myosin interactions: implications for cell therapy},
  author={Onnik Agbulut and Catherine Coirault and Nicolas Niederl{\"a}nder and Alexis Huet and Patrick Vicart and Albert Hagege and Michel Puc{\'e}at and Philippe Menasch{\'e}},
  journal={Nature Methods},
  year={2006},
  volume={3},
  pages={331-331}
}
To the editor: One of the major issues of cell transplantation is the in vivo tracking of injected cells to monitor their phenotypic changes and correlate engraftment with function. To this end, GFP and its variants have been most commonly used1,2. Although expression of GFP is considered to be innocuous for the cells, deleterious effects have been reported in in vitro3,4 and in vivo studies5,6, and include the development of dilated cardiomyopathy in mice5. The therapeutic potential of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…