GFP expression by intracellular gene delivery of GFP-coding fragments using nanocrystal quantum dots.

@article{Hoshino2008GFPEB,
  title={GFP expression by intracellular gene delivery of GFP-coding fragments using nanocrystal quantum dots.},
  author={Akiyoshi Hoshino and Noriyoshi Manabe and Kouki Fujioka and Sanshiro Hanada and Masato Yasuhara and Akihiko Kondo and Kenji Yamamoto},
  journal={Nanotechnology},
  year={2008},
  volume={19 49},
  pages={495102}
}
Gene therapy is an attractive approach to supplement a deficient gene function. Although there has been some success with specific gene delivery using various methods including viral vectors and liposomes, most of these methods have a limited efficiency or also carry a risk for oncogenesis. We herein report that quantum dots (QDs) conjugated with nuclear localizing signal peptides (NLSP) successfully introduced gene-fragments with promoter elements, which promoted the expression of the enhanced… CONTINUE READING