GFP-expressing influenza a virus for evaluation of the efficacy of antiviral agents


To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.

DOI: 10.1007/s12275-012-2163-9

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@article{Kim2012GFPexpressingIA, title={GFP-expressing influenza a virus for evaluation of the efficacy of antiviral agents}, author={Jin Il Kim and Sehee Park and Ilseob Lee and Sangmoo Lee and Saem Shin and Yongkwan Won and Min-Woong Hwang and Joon-Yong Bae and Jun Heo and Hye-Eun Hyun and Hyejin Jun and Soon Sung Lim and Man-Seong Park}, journal={The Journal of Microbiology}, year={2012}, volume={50}, pages={359-362} }