GFAP-Driven GFP Expression in Activated Mouse Müller Glial Cells Aligning Retinal Blood Vessels Following Intravitreal Injection of AAV2/6 Vectors

@inproceedings{Aartsen2010GFAPDrivenGE,
  title={GFAP-Driven GFP Expression in Activated Mouse M{\"u}ller Glial Cells Aligning Retinal Blood Vessels Following Intravitreal Injection of AAV2/6 Vectors},
  author={Wendy M. Aartsen and Koen W. R. van Cleef and Lucie P Pellissier and Robert M. Hoek and Rogier M. Vos and Bas Blits and Erich M. E. Ehlert and Kamaljit S. Balaggan and Robin R Ali and Joost Verhaagen and Jan Wijnholds},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Müller cell gliosis occurs in various retinal pathologies regardless of the underlying cellular defect. Because activated Müller glial cells span the entire retina and align areas of injury, they are ideal targets for therapeutic strategies, including gene therapy. METHODOLOGY/PRINCIPAL FINDINGS We used adeno-associated viral AAV2/6 vectors to transduce mouse retinas. The transduction pattern of AAV2/6 was investigated by studying expression of the green fluorescent protein (GFP… CONTINUE READING