GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression.

@article{Sakai2002GEX1CN,
  title={GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression.},
  author={Yasushi Sakai and Tetsuya Tsujita and Tadakazu Akiyama and Tatsuhiko Yoshida and Tamio Mizukami and Shiro Akinaga and Sueharu Horinouchi and Minoru Yoshida and Tetsuo Yoshida},
  journal={The Journal of antibiotics},
  year={2002},
  volume={55 10},
  pages={863-72}
}
Six GEX1 compounds, GEX1A/herboxidiene and its related 5 novel compounds, were isolated from a culture broth of Streptomyces sp. GEX1 compounds induced both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38. All six compounds up-regulated luciferase reporter gene expression directed by enhancer/promoter of various genes, such as cdc2, IL-2 and SV40 early genes. All GEX1 compounds showed cytotoxic activities in the same order of the up-regulating activities on gene expression… CONTINUE READING

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