GENETICS OF CLASSIC ALPORT'S SYNDROME

@article{Flinter1988GENETICSOC,
  title={GENETICS OF CLASSIC ALPORT'S SYNDROME},
  author={FrancesA Flinter and Cyril Chantler and John Stewart Cameron and Ian Houston and Martin Bobrow},
  journal={The Lancet},
  year={1988},
  volume={332},
  pages={1005-1007}
}
41 families with classic Alport's syndrome (hereditary nephritis with sensorineural deafness) were studied. All their pedigrees were compatible with X-linked inheritance. DNA probes were used to investigate genetic linkage in these families. Linkage to probe S21 (DXS17) was confirmed (LOD score = 4.72 at 0 = 0.06), localising the gene for Alport's syndrome to the middle of Xq; thus the disorder is X-chromosomal in nature. 
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