GENETIC STUDIES OF COMPLETE AND PARTIAL HYDATIDIFORM MOLES

@article{Lawler1979GENETICSO,
  title={GENETIC STUDIES OF COMPLETE AND PARTIAL HYDATIDIFORM MOLES},
  author={Sylvia D. Lawler and V. J. Pickthall and Rosemary Ann Fisher and Sue Povey and Mari Wyn Evans and Aron E. Szulman},
  journal={The Lancet},
  year={1979},
  volume={314}
}
Unmasking moles
TLDR
A new light was thrown on the subject when Kajii & Ohama (1977) demonstrated that complete moles are homozygous and androgenetic in that they lack any maternal contribution to the genome.
When a vesicular placenta meets a live fetus: case report of twin pregnancy with a partial hydatidiform mole
TLDR
A rare case of twin pregnancy comprising a partial mole and a normal fetus that resembled a singleton partial molar pregnancy is reported, which strongly recommends ancillary examinations in addition to traditional morphologic assessment in such cases.
Effect of Different Doses of Vitamin A on β-HCG Production in Patients Suffering from Gestational Trophoblastic Disease
TLDR
This study aimed to evaluate the effect of vitamin A doses (100,000 IU and 200,000IU) on the decrement of β-HCG levels in Gestational trophoblastic disease patients.
The hydatidiform mole
TLDR
In countries with poor medical health care system, moles can become invasive or, in rare cases, lead to gestational choriocarcinomas.
The microtubule-binding and coiled-coil domains of Kid are required to turn off the polar ejection force at anaphase
TLDR
It is proposed that phosphorylation of Thr463 switches the mitotic chromosome movement from an anti-poleward direction to a poleward direction by converting the Kid functional mode from polar-ejection-force-ON to -OFF during the metaphase–anaphase transition, and that both the second microtubule-binding domain and the coiled-coil domain are involved in this switching process.
Epigenetic mechanisms regulate placental c-myc and hTERT in normal and pathological pregnancies; c-myc as a novel fetal DNA epigenetic marker for pre-eclampsia.
TLDR
A role for epigenetic mechanisms in regulating differential expression of c-myc and hTERT during placental development and use of the c- myc promoter region as a potential fetal DNA marker in the case of PE is suggested.
Establishment of a new diagnostic method for hydropic villi by using TSSC3 antibody
TLDR
Results showed that a new diagnostic method was required for the management of patients with hydropic villi and identified the TSSC imprint gene, which expression was shown in normal and partial mole villi but was silenced in complete mole villa.
Partial Hydatidiform Mole: Histologic Parameters in Correlation With DNA Genotyping
  • N. Buza, P. Hui
  • Medicine
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 2013
TLDR
No single or combined morphologic features are sufficient for definitive diagnosis of PHM, and the presence of any one of the following histologic findings should prompt DNA genotyping workup to rule out PHM.
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References

SHOWING 1-9 OF 9 REFERENCES
Androgenesis as a cause of hydatidiform mole.
TLDR
Q-band chromosome studies were done in 3 molar conceptuses and their parents, with special attention to six pairs of chromosomes in which polymorphic variants occur frequently, suggesting that the moles inherited two morphologically identical haploid sets from the father and none from the mother.
Androgenetic origin of hydatidiform mole
TLDR
A cytogenetic study of the origin of hydatidiform mole is made and it is found that it receives only paternal chromosomes and is therefore androgenetic in origin.