GEF without a Dbl domain?


Guanine nucleotide-exchange factors (GEFs) interact with and activate members of the Rho family of small GTPases through Dbl homology (DH) domains. A new domain has been found in DOCK180 and shown to specifically activate Rho proteins. Interestingly, this module does not contain any homology to Dbl sequences.

DOI: 10.1038/ncb0802-e188


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@article{Braga2002GEFWA, title={GEF without a Dbl domain?}, author={Vania M M Braga}, journal={Nature Cell Biology}, year={2002}, volume={4}, pages={E188-E190} }