GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

@article{Rossman2005GEFMG,
  title={GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors},
  author={Kent L. Rossman and Channing J Der and John Sondek},
  journal={Nature Reviews Molecular Cell Biology},
  year={2005},
  volume={6},
  pages={167-180}
}
Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate numerous cellular responses such as proliferation, differentiation and movement. With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate Rho GTPases within particular spatio-temporal contexts. The failure to do so can have significant… CONTINUE READING
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