• Corpus ID: 211010888

GEANT4 simulation of a new range verification method using delayed gamma spectroscopy of a Mo-92 marker

  title={GEANT4 simulation of a new range verification method using delayed gamma spectroscopy of a Mo-92 marker},
  author={Eva Kasanda and C Burbadge and Vinzenz Bildstein and J. Turko and Artemis Spyrou and Cornelia Hohr and D. Mucher},
  journal={arXiv: Medical Physics},
In this work, we propose a novel technique for in-vivo proton therapy range verification. This technique makes use of a small hadron tumour marker, $^{92}$Mo, implanted at a short known distance from the clinical treatment volume. Signals emitted from the marker during treatment can provide a direct measurement of the proton beam energy at the marker's position. Fusion-evaporation reactions between the proton beam and marker nucleus result in the emission of delayed characteristic $\gamma$ rays… 



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The first tests of the timing method at a clinical proton accelerator are summarized, its applicability in a clinical environment for challenging the current safety margins is assessed, and the factors limiting its precision are discussed.

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Range uncertainties in proton therapy and the role of Monte Carlo simulations

  • H. Paganetti
  • Physics, Medicine
    Physics in medicine and biology
  • 2012
A significant impact of Monte Carlo dose calculation can be expected in complex geometries where local range uncertainties due to multiple Coulomb scattering will reduce the accuracy of analytical algorithms and in these cases Monte Carlo techniques might reduce the range uncertainty by several mm.

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In this review, state-of-the art in vivo proton range verification methods currently being proposed, developed or clinically implemented are described and compared.

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