GEANT4 Monte Carlo simulations for virtual clinical trials in breast X-ray imaging: Proof of concept.

@article{diFranco2020GEANT4MC,
  title={GEANT4 Monte Carlo simulations for virtual clinical trials in breast X-ray imaging: Proof of concept.},
  author={Francesca di Franco and Antonio Sarno and Giovanni Mettivier and A.M. Hernandez and Kristina Bliznakova and J Boone and Paolo Russo},
  journal={Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics},
  year={2020},
  volume={74},
  pages={
          133-142
        }
}
  • F. di Franco, A. Sarno, P. Russo
  • Published 26 May 2020
  • Medicine, Physics
  • Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
Virtual Clinical Trials in 2D and 3D X-ray Breast Imaging and Dosimetry: Comparison of CPU-Based and GPU-Based Monte Carlo Codes
TLDR
This work aims to compare three different platforms for breast VCT studies, to develop real-time virtual DM, DBT and BCT examinations, where the in-silico image acquisition process takes a computational time comparable to that typical of a corresponding real clinical examination.
Dataset of patient-derived digital breast phantoms for in-silico studies in breast computed tomography, digital breast tomosynthesis and digital mammography.
TLDR
The dataset developed within the INFN AGATA project will be used for developing a platform for virtual clinical trials in x-ray breast imaging and dosimetry and will represent a valid support for introducing new breast models for dose estimates in 2D and 3D x-rays Breast imaging and as models for manufacturing anthropomorphic physical phantoms.
Empirical detector model for simulated breast exams with a dedicated breast CT scanner
TLDR
The model for the case of cone-beam computed tomography dedicated to the breast that uses a indirect conversion flat-panel detector for direct conversion a-Se detectors used in digital mammography and digital breast tomosynthesis is introduced.
Voxelized Breast Phantoms for Dosimetry in Mammography
TLDR
A new heterogeneous digital breast model is proposed, involving a voxelized approach and disengaging from the concept of homogeneous phantom, to evaluate mean glandular dose discrepancies with the traditional model which is adopted in clinic for decades.
Technical Note: MC-GPU breast dosimetry validations with other Monte Carlo codes and Phase Space File implementation.
TLDR
The results indicate that MC-GPU code is suitable for breast dosimetric studies for different x-ray breast imaging modalities, with the advantage of a high performance derived from GPUs.
The advent of anthropomorphic three-dimensional breast phantoms for X-ray imaging.
  • K. Bliznakova
  • Medicine
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2020
Simulated sensor characterization for virtual clinical trials in mammography and digital breast tomosynthesis
Virtual clinical trials in X-ray breast imaging permit to compare different technical solutions and imaging modalities at reduced costs, involved personnel, reduced times and reduced radiation risks
Comparisons of glandular breast dose between digital mammography, tomosynthesis and breast CT based on anthropomorphic patient-derived breast phantoms.
Breast glandularity and mean glandular dose assessment using a deep learning framework: Virtual patients study.
  • Rodrigo T Massera, A. Tomal
  • Medicine, Physics
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2021
Normalized glandular dose coefficients for digital breast tomosynthesis systems with a homogeneous breast model
TLDR
The DgNDBT coefficients are proposed as unique conversion coefficients for MGD estimates, in place of dose conversion coefficients in mammography (DgNDM or c, g, s triad as proposed in worldwide quality assurance protocols) used together with the T correction factor.
...
...

References

SHOWING 1-10 OF 45 REFERENCES
Advanced Monte Carlo application for in-silico clinical trials in x-ray breast imaging
TLDR
A platform for virtual clinical trials in 2D and 3D x-ray breast imaging and digital patient exposures with the available phantom dataset will be possible for the same patient-derived phantom in uncompressed or compressed format, in DM, DBT and BCT modalities.
Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans
TLDR
A platform for virtual (in silico) clinical trials in x-ray breast imaging and dosimetry fully based on Monte Carlo simulations and which adopts patient-like digital phantoms is developed.
Virtual clinical trial of lesion detection in digital mammography and digital breast tomosynthesis
TLDR
The authors' VCTs showed an average AUC improvement for DBT vs DM of 0.027 for microcalcifications and 0.103 for masses, in close agreement (within 1%) of clinical data reported in the literature.
Development and validation of a modelling framework for simulating 2D-mammography and breast tomosynthesis images
TLDR
Two image simulation chains constructed using modelling tools that can be used for the evaluation of 2D-mammography and DBT systems are presented and it is suggested that the simulation approach is a promising alternative to conventional physical performance assessment followed by large scale clinical trials.
Dedicated breast CT: radiation dose and image quality evaluation.
TLDR
The potential of high signal-to-noise ratio images with low anatomic noise, which are obtainable at dose levels comparable to those for mammography, suggests that dedicated breast CT should be studied further for its potential in breast cancer screening and diagnosis.
Evaluation of a breast software model for 2D and 3D X-ray imaging studies of the breast.
  • Y. Baneva, K. Bliznakova, Z. Bliznakov
  • Physics, Medicine
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2017
Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models.
  • A. Sarno, G. Mettivier, P. Russo
  • Physics, Medicine
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2018
Evaluation of Dose Homogeneity in Cone-Beam Breast Computed Tomography
TLDR
Results from MC simulations indicate a significantly lower spread of volume dose than in mammography, which might be useful when devising models for breast imaging dose assessment that take into account the uneven distribution of the glandular mass in the breast volume.
Average glandular dose coefficients for pendant‐geometry breast CT using realistic breast phantoms
TLDR
To design volume‐specific breast phantoms from breast CT (bCT) data sets and estimate the associated normalized mean glandular dose coefficients for breast CT using Monte Carlo methods, a large cohort of bCT data sets across a range of six breast sizes was designed.
Technical Note - In silico imaging tools from the VICTRE clinical trial.
TLDR
The set of in silico imaging software tools used in the VICTRE (Virtual Clinical Trial for Regulatory Evaluation) which replicated a traditional trial using a computational pipeline is described.
...
...