GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing

@article{Filarsky2018GDV1IS,
  title={GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing},
  author={Michael Filarsky and Sabine A Fraschka and Igor Niederwieser and Nicolas M B Brancucci and Eilidh Carrington and Elvira Carri{\'o} and Suzette Moes and Paul Jenoe and Rich{\'a}rd B{\'a}rtfai and Till S Voss},
  journal={Science},
  year={2018},
  volume={359},
  pages={1259-1263}
}
Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only forms able to infect the mosquito vector and transmit malaria. Sexual commitment is triggered by activation of AP2-G, the master transcriptional regulator of gametocytogenesis. Heterochromatin protein 1 (HP1)–dependent silencing of ap2-g prevents sexual conversion in proliferating parasites. In this study, we identified Plasmodium… CONTINUE READING
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