GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells

@article{Shi2010GDP366AN,
  title={GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells},
  author={Xianping Shi and Deping Wang and K. Ding and Zhongzheng Lu and Y. Jin and J. Zhang and J. Pan},
  journal={Cancer Biology & Therapy},
  year={2010},
  volume={9},
  pages={640 - 650}
}
  • Xianping Shi, Deping Wang, +4 authors J. Pan
  • Published 2010
  • Biology, Medicine
  • Cancer Biology & Therapy
  • Accumulating evidence indicates that survivin plays a pivotal role in not only cell survival but also cell cycle progression. Op18/stathmin is an oncoprotein that regulates microtubule stabilization. Both survivin and Op18 have been proposed as therapeutic targets for cancer. However, few small molecule inhibitors of survivin and Op18 have been reported. In this study, we have identified a novel small molecule compound (GDP366) which potently and selectively inhibited the expression of both… CONTINUE READING
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    References

    SHOWING 1-10 OF 35 REFERENCES
    SPC3042: a proapoptotic survivin inhibitor
    • 93
    • PDF
    Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers
    • 59
    Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics
    • 662
    • PDF
    p21 is necessary for the p53-mediated G1 arrest in human cancer cells.
    • 1,221
    Stathmin 1: a novel therapeutic target for anticancer activity
    • 129
    If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.
    • I. Roninson, E. Broude, B. Chang
    • Biology, Medicine
    • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
    • 2001
    • 692
    Oncoprotein 18 is a phosphorylation‐responsive regulator of microtubule dynamics.
    • 260