GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells

@article{Shi2010GDP366AN,
  title={GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells},
  author={Xianping Shi and Deping Wang and Ke Ding and Zhongzheng Lu and Yanli Jin and Jin Zhang and Jingxuan Pan},
  journal={Cancer Biology \& Therapy},
  year={2010},
  volume={9},
  pages={640 - 650}
}
Accumulating evidence indicates that survivin plays a pivotal role in not only cell survival but also cell cycle progression. Op18/stathmin is an oncoprotein that regulates microtubule stabilization. Both survivin and Op18 have been proposed as therapeutic targets for cancer. However, few small molecule inhibitors of survivin and Op18 have been reported. In this study, we have identified a novel small molecule compound (GDP366) which potently and selectively inhibited the expression of both… 
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Results indicated that GDP366 and AD80 reduced the PI3K/STMN1 axis and had cytotoxic effects in acute leukemia cellular models, which highlight STMN1-mediated signaling as a putative anticancer target for acute leukemia.
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Multiple molecular approaches such as use of the RNA interfering technique, antisense oligonucleotides, ribozyme, and small molecule inhibitors have been used to downregulate survivin regulation and inhibit its biological function consequently.
A combination of paclitaxel and siRNA-mediated silencing of Stathmin inhibits growth and promotes apoptosis of nasopharyngeal carcinoma cells
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It is found that siRNA-mediated silencing of Stathmin suppresses proliferation, induces apoptosis through the mitochondrial pathway, and causes G2/M-phase cell cycle arrest in the NPC cell lines CNE1-LMP1 and HNE2.
Survivin: a unique target for tumor therapy
TLDR
Overall, Survivin emerges as a molecule with much wider role in cellular homeostasis and its role in regulation of apoptosis, cell division, chemo-resistance and tumour progression is discussed.
Therapeutic strategies involving survivin inhibition in cancer
TLDR
In this review, recent progress in the therapeutic options targeting survivin for cancer treatment is analyzed and the major signaling pathways implicated in survivin regulation are described and different therapeutic approaches involving survivin indirect inhibition are evaluated.
Discovery of survivin inhibitors and beyond: FL118 as a proof of concept.
  • Fengzhi Li
  • Biology
    International review of cell and molecular biology
  • 2013
Therapeutic strategies involving survivin inhibition in cancer Running title: Survivin inhibition in cancer therapy
TLDR
In this review, recent progress in the therapeutic options targeting survivin for cancer treatment is analyzed and the major signalling pathways implicated in survivin regulation are described and different therapeutic approaches involving survivin indirect inhibition are evaluated.
Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy.
Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics
TLDR
The expression of survivin in normal and cancer cells is analyzed with a particular focus on its expression in cancer stem cell compartment and the challenges involving the development of potent and specific survivin inhibitors for cancer therapeutics are discussed.
Survivin and gynaecological tumours.
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