GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability of Aspergillus fumigatus.

@article{Jiang2008GDPmannosePI,
  title={GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability of Aspergillus fumigatus.},
  author={Hechun Jiang and Haomiao Ouyang and Hui Zhou and Cheng Jin},
  journal={Microbiology},
  year={2008},
  volume={154 Pt 9},
  pages={
          2730-9
        }
}
GDP-mannose pyrophosphorylase (GMPP) catalyses the synthesis of GDP-mannose, which is the precursor for the mannose residues in glycoconjugates, using mannose 1-phosphate and GTP as substrates. Repression of GMPP in yeast leads to phenotypes including cell lysis, defective cell wall, and failure of polarized growth and cell separation. Although several GMPPs have been isolated and characterized in filamentous fungi, the physiological consequences of their actions are not clear. In this study… CONTINUE READING

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