GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis

@article{Planas2018GDPlfucoseSI,
  title={GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis},
  author={Raquel Planas and Radleigh G. Santos and Paula Tomas-Ojer and Carolina Cruciani and Andreas Lutterotti and Wolfgang Faigle and Nicole Schaeren-Wiemers and Carmen Espejo and Herena Eixarch and Clemencia Pinilla and Roland Martin and Mireia Sospedra},
  journal={Science Translational Medicine},
  year={2018},
  volume={10}
}
GDP-l-fucose synthase is an autoantigen recognized by cerebrospinal fluid–infiltrating CD4+ T cells from HLA-DRB3* patients with multiple sclerosis. Move over myelin Although it is well established that autoreactive lymphocytes induce demyelination in multiple sclerosis, the exact antigenic targets that initiate disease are undefined. Planas et al. studied CD4+ T cells from the cerebrospinal fluid of patients with multiple sclerosis. One CD4+ T cell clone was reactive to the human enzyme GDP-l… 
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53 Citations
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53 Citations

Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
TLDR
This work screened for T cell autoreactivity against 63 CNS-expressed proteins using a novel in vitro antigen delivery method combined with the Human Protein Atlas library and identified four previously unreported autoantigens in MS, which were verified to induce interferon-γ responses in MS in two cohorts.
T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis
TLDR
An association between autoantigen reactivity and features of disease heterogeneity that strongly supports an important role of T-cell specificity in MS pathogenesis is revealed.
Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis
TLDR
It is concluded that citrullination does not appear to be an important activating factor of a T cell response, but could be the consequence of an immune- or inflammatory response.
HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis
Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis
TLDR
An increased proportion of myelin-specific CD8+ T cells in MS patients exhibited a memory phenotype and expressed CD20 compared to control subjects, while there were no phenotypic differences observed among influenza-specificCD8+T cells.
The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis Pathogenesis
TLDR
The results of human studies that have contributed to elucidate the role of CD8 T cells in MS immunopathogenesis are reviewed, and current understanding of autoreactivity, B-cell and EBV involvement in MS, and mechanism of action of different MS treatments are discussed.
HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis.
Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS
TLDR
Oligodendrocyte myelin glycoprotein (OMGP) as autoimmune target is investigated, and it is found that OMGP-specific T cells induce a novel type of experimental autoimmune encephalomyelitis dominated by meningitis above the cortical convexities in an animal model.
Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells.
CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome
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