GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis

@article{Planas2018GDPlfucoseSI,
  title={GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis},
  author={Raquel Planas and Radleigh G Santos and Paula Tomas-Ojer and Carolina Cruciani and Andreas Lutterotti and Wolfgang Faigle and Nicole Schaeren-Wiemers and Carmen Espejo and Herena Eixarch and Clemencia Pinilla and Roland Martin and Mireia Sospedra},
  journal={Science Translational Medicine},
  year={2018},
  volume={10}
}
GDP-l-fucose synthase is an autoantigen recognized by cerebrospinal fluid–infiltrating CD4+ T cells from HLA-DRB3* patients with multiple sclerosis. Move over myelin Although it is well established that autoreactive lymphocytes induce demyelination in multiple sclerosis, the exact antigenic targets that initiate disease are undefined. Planas et al. studied CD4+ T cells from the cerebrospinal fluid of patients with multiple sclerosis. One CD4+ T cell clone was reactive to the human enzyme GDP-l… Expand
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