GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis

  title={GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis},
  author={Min-Chi Ku and Susanne A Wolf and Dorota Respondek and Vitali Matyash and Andreas Pohlmann and Sonia Waiczies and Helmar Waiczies and Thoralf Niendorf and M Synowitz and Rainer Glass and Helmut Kettenmann},
  journal={Acta Neuropathologica},
High-grade gliomas are the most common primary brain tumors. Their malignancy is promoted by the complex crosstalk between different cell types in the central nervous system. Microglia/brain macrophages infiltrate high-grade gliomas and contribute to their progression. To identify factors that mediate the attraction of microglia/macrophages to malignant brain tumors, we established a glioma cell encapsulation model that was applied in vivo. Mouse GL261 glioma cell line and human high-grade… CONTINUE READING


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