GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier.

@article{Boado2008GDNFFP,
  title={GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier.},
  author={Ruben J. Boado and Yun Zhang and Yufeng Zhang and Yuntao Wang and William M Pardridge},
  journal={Biotechnology and bioengineering},
  year={2008},
  volume={100 2},
  pages={387-96}
}
Glial-derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the blood-brain barrier (BBB). Human GDNF was re-engineered by fusion of the mature GDNF protein to the carboxyl terminus of the chimeric monoclonal antibody (MAb) to the human insulin receptor (HIR). The HIRMAb-GDNF fusion protein is bi-functional, and both binds the HIR, to trigger receptor-mediated… CONTINUE READING

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Glial - derived neurotrophic factor ( GDNF ) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson 's disease , stroke , and motor neuron disease .
Glial - derived neurotrophic factor ( GDNF ) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson 's disease , stroke , and motor neuron disease .
Glial - derived neurotrophic factor ( GDNF ) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson 's disease , stroke , and motor neuron disease .
Glial - derived neurotrophic factor ( GDNF ) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson 's disease , stroke , and motor neuron disease .
Human GDNF was re - engineered by fusion of the mature GDNF protein to the carboxyl terminus of the chimeric monoclonal antibody ( MAb ) to the human insulin receptor ( HIR ) .
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