GDNF and NGF reverse changes in repriming of TTX-sensitive Na(+) currents following axotomy of dorsal root ganglion neurons.

@article{Leffler2002GDNFAN,
  title={GDNF and NGF reverse changes in repriming of TTX-sensitive Na(+) currents following axotomy of dorsal root ganglion neurons.},
  author={Andreas Leffler and Theodore R. Cummins and Sulayman D. Dib-Hajj and William N Hormuzdiar and J Andrew Black and Stephen G. Waxman},
  journal={Journal of neurophysiology},
  year={2002},
  volume={88 2},
  pages={650-8}
}
Uninjured C-type rat dorsal root ganglion (DRG) neurons predominantly express slowly inactivating TTX-resistant (TTX-R) and slowly repriming TTX-sensitive (TTX-S) Na(+) currents. After peripheral axotomy, TTX-R current density is reduced and rapidly repriming TTX-S currents emerge and predominate. The change in TTX-S repriming kinetics is paralleled by an increase in the level of transcripts and protein for the Na(v)1.3 sodium channel alpha-subunit, which is known to exhibit rapid repriming… CONTINUE READING

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