GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?

@article{Airaksinen1999GDNFFN,
  title={GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?},
  author={Matti S. Airaksinen and Alexey Titievsky and Mart Saarma},
  journal={Molecular and Cellular Neuroscience},
  year={1999},
  volume={13},
  pages={313-325}
}
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References

SHOWING 1-10 OF 116 REFERENCES
GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family
TLDR
A third member of the GF coreceptor family called GFRα3 that is encoded by a gene located on human chromosome 5q31.2–32 is described, which is not expressed in the central nervous system of the developing or adult animal but is highly expressed in several developing and adult sensory and sympathetic ganglia of the peripheral nervous system.
Molecular Cloning and Expression Analysis of GFRα-3, a Novel cDNA Related to GDNFRα and NTNRα
TLDR
Results indicate that the tissue distribution of GFR alpha-3 mRNA is different from that of GDNFR alpha or NTNR alpha mRNA, and suggest that GFRalpha-3 may function in differentiation of embryonic cells expressing its mRNA.
GFRα-2 and GFRα-3 Are Two New Receptors for Ligands of the GDNF Family
TLDR
The receptor for glial cell line-derived neurotrophic factor (GDNF) consists of GFRα-1 and Ret, and it is reported that neurturin can bind to either GFR α-1 or G FRα-2, a novel receptor related to GFRβ, suggesting that GFRs mediate the action of GDNF family ligands in vivo.
GFRα-4, a New GDNF Family Receptor
TLDR
The findings extend the family of GFRα proteins and provide information about the tissues in which GFR α-4 may function during development and predict a 431-amino-acid secreted protein that is more closely related to G FRα-1 and GFRalpha-2 than to GFRβ-3.
The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma
TLDR
It is demonstrated that Tyr-539 of Ret/ptc2 (Tyr-761 on the proto-RET product) is an essential docking site for the full transforming potential of the oncogene, and PLCgamma is identified as a downstream effector ofRet/ptcs and suggested that this transducing molecule could play a crucial role in neoplastic signalling triggered by Ret/PTc oncoproteins.
Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons.
TLDR
It is demonstrated that NTN induces Ret phosphorylation in primary cultures of rat superior cervical ganglion (SCG) neurons, and data indicate that NTn is a physiologically relevant ligand for the Ret receptor and suggest thatNTN may have a critical role in the development of many neuronal populations.
Mutations of the RET-GDNF signaling pathway in Ondine's curse.
This study was supported by the Association pour la Recherche sur le Cancer, the Association Francaise contre les Myopathies, and the Projet Hospitalier de Recherche Clinique (grant AOA94060). We
Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase*
TLDR
It is demonstrated that GDNF treatment of several neuroblastoma cell lines leads to dose-dependent tyrosine phosphorylation of the RET receptor and that other transforming growth factor-β family members are not able to activate the RET receptors.
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