GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle.

  title={GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle.},
  author={C. E. Henderson and H. Phillips and R. A. Pollock and A. Davies and C. Lemeulle and M. Armanini and L. Simmons and B. Moffet and R. Vandlen and L. Simpson LC corrected to Simmons and V. Koliatsos and A. Rosenthal},
  volume={266 5187},
  • C. E. Henderson, H. Phillips, +9 authors A. Rosenthal
  • Published 1994
  • Biology, Medicine
  • Science
  • For survival, embryonic motoneurons in vertebrates depend on as yet undefined neurotrophic factors present in the limb bud. Members of the neurotrophin family are currently the best candidates for such neurotrophic factors, but inactivation of their receptor genes leads to only partial loss of motoneurons, which suggests that other factors are involved. Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to… CONTINUE READING
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