GDI-Mediated Cell Polarization in Yeast Provides Precise Spatial and Temporal Control of Cdc42 Signaling

@inproceedings{Klnder2013GDIMediatedCP,
  title={GDI-Mediated Cell Polarization in Yeast Provides Precise Spatial and Temporal Control of Cdc42 Signaling},
  author={Ben Kl{\"u}nder and Tina Freisinger and Roland Wedlich-S{\"o}ldner and Erwin Frey},
  booktitle={PLoS Computational Biology},
  year={2013}
}
Cell polarization is a prerequisite for essential processes such as cell migration, proliferation or differentiation. The yeast Saccharomyces cerevisiae under control of the GTPase Cdc42 is able to polarize without the help of cytoskeletal structures and spatial cues through a pathway depending on its guanine nucleotide dissociation inhibitor (GDI) Rdi1. To develop a fundamental understanding of yeast polarization we establish a detailed mechanistic model of GDI-mediated polarization. We show… CONTINUE READING
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