GDF15 triggers homeostatic proliferation of acid-secreting collecting duct cells.

@article{Huyen2008GDF15TH,
  title={GDF15 triggers homeostatic proliferation of acid-secreting collecting duct cells.},
  author={Jean Paul Duong Van Huyen and Lydie Cheval and May Bloch-Faure and Marie France Belair and Didier Heudes and Patrick Bruneval and Alain Doucet},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2008},
  volume={19 10},
  pages={1965-74}
}
Although adult kidney cells are quiescent, enlargement of specific populations of epithelial cells occurs during repair and adaptive processes. A prerequisite to the development of regenerative therapeutics is to identify the mechanisms and factors that control the size of specific populations of renal cells. Unfortunately, in most cases, it is unknown whether the growth of cell populations results from transdifferentiation or proliferation and whether proliferating cells derive from epithelial… CONTINUE READING

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