GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.

@article{Xu2006GDF15MIC1FA,
  title={GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.},
  author={J Xu and Thomas R. Kimball and John N. Lorenz and David Adam Brown and Asne R. Bauskin and Raisa Klevitsky and Timothy E. Hewett and Samuel N Breit and Jeffery D Molkentin},
  journal={Circulation research},
  year={2006},
  volume={98 3},
  pages={342-50}
}
Here we identified growth-differentiation factor 15 (GDF15) (also known as MIC-1), a secreted member of the transforming growth factor (TGF)-beta superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy. To elucidate the function of GDF15 in the heart, we generated transgenic mice with cardiac-specific overexpression. GDF15 transgenic mice… CONTINUE READING
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